Tight junctions. Their structure, composition, and function.
نویسندگان
چکیده
منابع مشابه
BRIEF REVIEWS Tight Junctions Their Structure, Composition, and Function
THE tight junction or zonula occludens was first described in epithelia over 20 years ago (Farquhar and Palade, 1963). Since then, a large number of studies have been carried which show that the structure, composition, and regulation of this specialized region of plasma membrane is critical to the barrier function of these epithelia. In addition to serving as a permeability barrier, delimiting ...
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The skin is an indispensable barrier which protects the body from the uncontrolled loss of water and solutes as well as from chemical and physical assaults and the invasion of pathogens. In recent years several studies have suggested an important role of intercellular junctions for the barrier function of the epidermis. In this review we summarize our knowledge of the impact of adherens junctio...
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Tight junctions form the major paracellular barrier in epithelial tissues. Barrier-sealing properties are quite variable among cell types in terms of electrical resistance, solute and water flux, and charge selectivity. A molecular explanation for this variability appears closer following identification of the transmembrane proteins occludin and members of the claudin multigene family. For exam...
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Epithelial cells cover the body (e.g. skin), cavities (e.g. stomach, uterus, bladder) and ducts (e.g. renal tubules, intestine) of multicellular organisms, and thus constitute the frontier between the individual and the external milieu. In areas that withstand strong mechanical or chemical stress (e.g. skin, esophagus, cornea, vagina) epithelia are stratified, whereas in the rest of the body, t...
متن کاملTight junctions
part of my lab in that direction with work on human embryonic stem cells which, as we have come to learn, show aberrant epigenetic regulation. There is a lot to learn from this much needed human model. What do you enjoy most about science? The challenge, the discovery, and the people. In this profession, one meets some of the brightest (and most eccentric) minds on Earth. Although I dislike air...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1984
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.55.6.723